H. Lee Moffitt Cancer Center & Research Institute

Metastatic Squamous Neck Cancer With Occult Primary

Head and Neck Program

Treatment Option Overview

How metastatic squamous neck cancer with occult primary is treated

There are treatments for all patients with metastaticsquamous neck cancer with occult primary. Two kinds of treatment are used:

  • Surgery (taking out the cancer).
  • Radiation therapy (using high-dosex-rays or other high-energy rays to kill cancer cells).

Chemotherapy is being studied in clinical trials.

Surgery is a common treatment of metastatic neck cancer. A doctor may cut out the lymph nodes that contain cancer and some of the healthy lymph nodes around them (lymph node dissection).

Radiation therapy uses high-energy x-rays to kill cancer cells and shrink tumors.Radiation may come from a machine outside the body (external radiation therapy) or from putting materials that produce radiation (radioisotopes) through thin plastic tubes that are put into the area where the cancer cells are found (internal radiation therapy). External radiation to the thyroid or the pituitary gland may change the way the thyroid gland works. The doctor may wish to test the thyroid gland before and after therapy to make sure it is working properly.

Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in a vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells outside the neck.

Treatment by stage

Treatment of metastatic squamous neck cancer with occult primary depends on how many lymph nodes contain cancer, whether or not an original (primary) tumor is found, and the patient’s age and overall condition.

Standard treatment may be considered because of its effectiveness in patients in past studies, or participation in a clinical trial may be considered. Not all patients are cured with standard therapy and some standard treatments may have more side effects than are desired. For these reasons, clinical trials are designed to find better ways to treat cancer patients and are based on the most up-to-date information. Clinical trials are ongoing in some parts of the country for metastatic squamous neck cancer. To learn more about clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237); TTY at 1-800-332-8615.


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